Synthesis of a Phosphoserine Mimetic Prodrug with Potent 14-3-3 Protein Inhibitory Activity
نویسندگان
چکیده
منابع مشابه
Interaction of 14-3-3 with Signaling Proteins Is Mediated by the Recognition of Phosphoserine
The highly conserved and ubiquitously expressed 14-3-3 family of proteins bind to a variety of proteins involved in signal transduction and cell cycle regulation. The nature and specificity of 14-3-3 binding is, however, not known. Here we show that 14-3-3 is a specific phosphoserine-binding protein. Using a panel of phosphorylated peptides based on Raf-1, we have defined the 14-3-3 binding mot...
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ژورنال
عنوان ژورنال: Chemistry & Biology
سال: 2012
ISSN: 1074-5521
DOI: 10.1016/j.chembiol.2012.05.011